On behalf of the Co-Operative Studies on Brain Injury Depolarisations (COSBID), the Local Organizing Committee and Program Committee, we wish you a warm welcome to the International Conference on Spreading Depolarisations 2025 (iCSD 2025), to be held in Windsor, UK between 8th and 11th December 2025. The Venue of the meeting will be the De Vere Beaumont Estate, Old Windsor, SL4 2JJ, UK.

Following the traditions of previous annual meetings of the COSBID group, iCSD 2025 will promote translational research on spreading depolarisation in acute brain injury and chronic brain disorders. Discussions about fundamental mechanisms of spreading depolarisation (SD) as well as ongoing and future applications at the bedside will be discussed. The goal of the iCSD conferences is to provide education on spreading depolarisations and present the latest discoveries within this growing field.

For iCSD2025 we have designed the programme to appeal to neurointensivists (including those in the UK contributing to TBI-Reporter), and to epileptologists, reflecting increasing recognition of the apparent (patho)physiological linkage of SDs and seizures.

De Vere Beaumont Estate Old Windsor SL4 2JJ UK

iCSD 2025 will take place in Windsor, within the grounds of a long-established country estate, close to the historical heart of England for the past thousand years, Windsor Castle. Spreading depolarisations (SDs) are recognised as a strong candidate mediator of acute brain damage in patients receiving neurocritical care, whether for traumatic brain injury, ischaemic or haemorrhagic stroke, or aneurysmal subarachnoid haemorrhage.

Please send us your abstracts on

  • Basic mechanisms & experimental models
  • Invasive and non-invasive detection of SDs
  • Effects of SDs on the cerebral microcirculation
  • Effects on brain metabolism
  • Long term effects on cognition and connectivity
  • Interactions of SDs with seizures
  • Acute phase clinical management

iCSD2025 is fully translational, offering around 50% clinical and 50% basic neuroscience over 3½ days.

  • Keynote presentations from leading clinical and basic neuroscientists.
  • Introductory educational half day on December 8th
  • Predominantly clinical presentations on December 9th. Free paper and poster sessions throughout the meeting.
  • Progress reports of clinical trials attract particular interest and are expected to be a feature of iCSD2025.
  • On 9th December there will be an option to attend Prof Peter Smielewski’s ICM+ course.

We very much look forward to your participation in iCSD 2025 and to welcoming you to Windsor, UK!

On behalf of the Co-Operative Studies on Brain Injury Depolarisations and
the Local Organizing Committee,

Yours Sincerely,

Sharon Jewell Sharon Jewell
King’s College London