Programme Outline
DAY 1, DECEMBER 8, MONDAY: Balmoral Suite, De Vere Beaumont Estate
12:00-13:00Registration for Day 1 Participants
13:00-15:30 Advanced monitoring in the neuroICU: scientific background, goals and methods
..and not just about spreading depolarisations
..and not just about spreading depolarisations
Pathobiology and monitoring in Traumatic Brain Injury
Professor Raimund Helbok: Chairman of Neurology, Keplerklinikum Linz
Pathophysiology first: technology second
Professor Raimund Helbok: Chairman of Neurology, Keplerklinikum Linz
Pathophysiology first: technology second
Understanding clinical pathophysiology through metabolic imaging
Professor Jonathan Coles, Intensive Care Medicine, University of Cambridge
Metabolic dysfunction is complex and spatially heterogeneous
Professor Jonathan Coles, Intensive Care Medicine, University of Cambridge
Metabolic dysfunction is complex and spatially heterogeneous
Spreading depolarisations in multimodal datastreams in the neuroICU: perhaps we CAN and should start to manage SDs in the neuroICU?
Professor Jed Hartings, Department of Neurosurgery, University of Cincinnati
Why we need to think about managing SDs
Professor Jed Hartings, Department of Neurosurgery, University of Cincinnati
Why we need to think about managing SDs
15:30-16:00Tea break
16:00-17:45Demonstration Workshop Advanced Neuromonitoring in the Age of AI
Enhancing the yield from continuous ECoG – including SDs
A version of this Workshop was very well received at the recent Annual Meeting of the Neurocritical Care Society
Minimally invasive subdural ECoG probe insertion (Ahilan Kailaya-Vasan, José-Pedro Lavrador, Department of Neurosurgery, King’s College Hospital – 7 min)
Connection of Spencer probe for subdural ECoG (Sharon Jewell, King’s College London – 7 min)
Automated SD detection: algorithm development and case review of application (Jed Hartings, Univ. of Cincinnati – 20 min)
Neuroinformatics and AI in the NeuroICU - 45 min
Introduction to Moberg platform (Craig Maddox, Ethan Moyer, Moberg Analytics)
Focus on implementation
The background to reviewing multimodal monitoring and how SDs fit in
OpenSD detection
Focus on real-time implementation
Python notebooks
Using the OpenSD algorithm
More visualization, less code, easy to follow
Q&A - 15 min
Enhancing the yield from continuous ECoG – including SDs
A version of this Workshop was very well received at the recent Annual Meeting of the Neurocritical Care Society
Minimally invasive subdural ECoG probe insertion (Ahilan Kailaya-Vasan, José-Pedro Lavrador, Department of Neurosurgery, King’s College Hospital – 7 min)
Connection of Spencer probe for subdural ECoG (Sharon Jewell, King’s College London – 7 min)
Automated SD detection: algorithm development and case review of application (Jed Hartings, Univ. of Cincinnati – 20 min)
Neuroinformatics and AI in the NeuroICU - 45 min
Introduction to Moberg platform (Craig Maddox, Ethan Moyer, Moberg Analytics)
Focus on implementation
The background to reviewing multimodal monitoring and how SDs fit in
OpenSD detection
Focus on real-time implementation
Python notebooks
Using the OpenSD algorithm
More visualization, less code, easy to follow
Q&A - 15 min
19:30-22:00Welcome Canapé Reception: Balmoral Suite Ground Floor Lounge
DAY 2, DECEMBER 9, TUESDAY Balmoral Suite: Parallel sessions
8:00-9:00Registration
8:45-9:00Welcome
9:00-18:00 Main Sessions: Room A+B
9:00-16:00 Parallel session (adjacent): ICM+ course: Prof Peter Smielewski and Dr. Erta Beqiri (See also below)
9:00-16:00 Parallel session (adjacent): ICM+ course: Prof Peter Smielewski and Dr. Erta Beqiri (See also below)
Chair: Sharon Jewell
9:00-10:00[K1] Impacts of circadian rhythm and sleep patterns on SD risk
Keynote: Philip Holland (King’s College London)
Keynote: Philip Holland (King’s College London)
10:00-10:40Prediction of SD
10:00-10:25[P1] ICUCockpit: IT infrastructure for the collection of multi-modal, high-resolution patient data and online validation of predictive algorithms in a live
Tilman Beck, Jan Willms, Una Pale, Jenny Schmid, Kay Müller, Emanuela Keller (University Hospital Zurich, Switzerland)
Tilman Beck, Jan Willms, Una Pale, Jenny Schmid, Kay Müller, Emanuela Keller (University Hospital Zurich, Switzerland)
10:25-10:40[O1] Influence of Systemic Secondary Brain Insults on Spreading Depolarization Frequency
Valentin Ghibaudo (Lyon Neuroscience Research Center, Lyon, France), Gwendan Percevault, Baptiste Balança
Valentin Ghibaudo (Lyon Neuroscience Research Center, Lyon, France), Gwendan Percevault, Baptiste Balança
10:40-11:05Coffee break
11:05-12:40Seizures and SD
Chair: Martin Fabricius
Chair: Martin Fabricius
11:05-11:20[O2] Thalamic Depolarization transiently suppresses widespread seizure activity in a rat model of oc-cipital lobe epilepsy
Robert Wykes (Research Department of Epilepsy, University College Queen Square Institute of Neurology, London)
Robert Wykes (Research Department of Epilepsy, University College Queen Square Institute of Neurology, London)
11:20-11:45[P2] Region-specific seizure-associated spreading depolarization as a key pathoclinical factor in epilepsy
Bence Mitlasóczki, Adrián Gutiérrez Gómez, Midia Kamali, Natalia Babushkina, Mayan Baues, Laura Kück, André Nathan Haubrich, Theodoros Tamiolakis, Annika Breuer, Simon Granak, Merlin Schwering-Sohnrey, Ingo Gerhauser, Wolfgang Baumgärtner, Martin Karl Schwarz, Laura Ewell, Thoralf Opitz, Julika Pitsch, Simon Musall, Rainer Surges, Florian Mormann, Heinz Beck, Michael Wenzel (University Hospital Bonn, Dept. of Epileptology, 53127 Bonn, Germany)
Bence Mitlasóczki, Adrián Gutiérrez Gómez, Midia Kamali, Natalia Babushkina, Mayan Baues, Laura Kück, André Nathan Haubrich, Theodoros Tamiolakis, Annika Breuer, Simon Granak, Merlin Schwering-Sohnrey, Ingo Gerhauser, Wolfgang Baumgärtner, Martin Karl Schwarz, Laura Ewell, Thoralf Opitz, Julika Pitsch, Simon Musall, Rainer Surges, Florian Mormann, Heinz Beck, Michael Wenzel (University Hospital Bonn, Dept. of Epileptology, 53127 Bonn, Germany)
11:45-12:10[P3] Mechanistic dissection of spreading depolarizations during ictal discharges
R. Ryley Parrish (Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA), Jacob Norby, Daniel Hummel, Rhiannon Cowan, Andrew J. Trevelyan, Elliot H. Smith
R. Ryley Parrish (Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA), Jacob Norby, Daniel Hummel, Rhiannon Cowan, Andrew J. Trevelyan, Elliot H. Smith
12:10-12:25[O3] Association of spreading depolarizations (SDs) with late post-traumatic seizures (PTS) after severe traumatic brain injury (TBI)
Kseniia Kriukova (Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA), Rachel E. Thomas, Ethan J. Moyer, Justin Moore, Humberto Mestre-Payne, Alex Vaz, Dmitriy Petrov, Danielle K. Sandsmark, Richard Moberg, Ramani Balu, James J. Gugger, Ramon Diaz-Arrastia, Dominique Duncan
Kseniia Kriukova (Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA), Rachel E. Thomas, Ethan J. Moyer, Justin Moore, Humberto Mestre-Payne, Alex Vaz, Dmitriy Petrov, Danielle K. Sandsmark, Richard Moberg, Ramani Balu, James J. Gugger, Ramon Diaz-Arrastia, Dominique Duncan
12:25-12:40[O4] A Regional Survey on NORSE Management in South East England
Mina Masoud (King's College Hospital, London, UK), C. Pahl, L. Nashef, F. Brunnhuber, H. Hasegawa, R. Selway, M. Tanaka, L. Mantoan
Mina Masoud (King's College Hospital, London, UK), C. Pahl, L. Nashef, F. Brunnhuber, H. Hasegawa, R. Selway, M. Tanaka, L. Mantoan
12:40-13:35Lunch
13:40-14:15Poster Session 1
Chair: Eszter Farkas
Chair: Eszter Farkas
[p1] Clinical risk factors of spreading depolarization development: a narrative review
Liangchen Guo (Department of Neuroanaestesiology, Department of Clinical Neurophysiology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark), Martin Ejler Fabricius, Kirsten Møller
Liangchen Guo (Department of Neuroanaestesiology, Department of Clinical Neurophysiology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark), Martin Ejler Fabricius, Kirsten Møller
[p2] Ketone bodies reduce spreading depolarization occurrence and impairment of mitochondrial respiratory capacity
Rachel Ricks, Tyler Poulos, Dallin S. Nevers, T. Luke Shafer, Benjamin T. Bikman, R. Ryley Parrish (Department of Cell Biology and Physiology, Neuroscience Center, Brigham Young University, Provo, Utah. 84602, USA)
Rachel Ricks, Tyler Poulos, Dallin S. Nevers, T. Luke Shafer, Benjamin T. Bikman, R. Ryley Parrish (Department of Cell Biology and Physiology, Neuroscience Center, Brigham Young University, Provo, Utah. 84602, USA)
[p3] Secondary Cortical Spreading Depression Due to Microembolism: A Case of Daily Migraine Aura-like Episodes with Therapeutic Response to Antiplatelets
Magnus Peter Brammer Kreiberg (Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark), Steffen Hamann, Sverre Rosenbaum, Kasper Rossing, Mari-Anne Gall, Cenk Ayata, Anders Hougaard
Magnus Peter Brammer Kreiberg (Department of Neurology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark), Steffen Hamann, Sverre Rosenbaum, Kasper Rossing, Mari-Anne Gall, Cenk Ayata, Anders Hougaard
[p4] Interaction of Spreading Depolarizations and Seizure Termination in Rat Models of Acquired Temporal Lobe Epilepsy
Alexandra Sommer (Department of Neurosciences, University of New Mexico Health Science Center, Albuquerque, NM), Davey Gregg, Sam McKenzie
Alexandra Sommer (Department of Neurosciences, University of New Mexico Health Science Center, Albuquerque, NM), Davey Gregg, Sam McKenzie
[p5] Co-existence of SD and Epileptic discharges – a case from the ongoing KETABID-study
Henning Piilgaard (Department of Clinical Neurophysiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Neurology, Zealand University Hospital, Roskilde, Denmark), Trine Hjorslev Andersen, Liangchen Guo, Kirsten Møller, Martin Fabricius
Henning Piilgaard (Department of Clinical Neurophysiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Department of Neurology, Zealand University Hospital, Roskilde, Denmark), Trine Hjorslev Andersen, Liangchen Guo, Kirsten Møller, Martin Fabricius
[p6] Changes of different speed ranges of regional cerebral blood flow during spreading depolarisation-induced spreading ischaemia in the rat cortex
Coline L. Lemale (Center for Stroke Research Berlin, Charité Universitätsmedizin, Germany; Experimental Neurology, Charité Universitätsmedizin, Germany), Jens P. Dreier
Coline L. Lemale (Center for Stroke Research Berlin, Charité Universitätsmedizin, Germany; Experimental Neurology, Charité Universitätsmedizin, Germany), Jens P. Dreier
[p7] Non-Invasive Methods for the Detection of Spreading Depolarisations: A Scoping Review
Elspeth Mabin (Critical Care, King's College Hospital), Ganesh Rajashanmagham, Masumi Tanaka
Elspeth Mabin (Critical Care, King's College Hospital), Ganesh Rajashanmagham, Masumi Tanaka
[p8] Remote Cortical Spreading Depolarization Triggered by Olfactory Bulb Stimulation in Mice
Lydia R. Hawley (Neurovascular Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129 USA ), Muhammed Miran Öncel, Elyssa M. Alber, Kathleen F. Vincent, Ken Solt, Cenk Ayata, Andreia Morais, David Y. Chung
Lydia R. Hawley (Neurovascular Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129 USA ), Muhammed Miran Öncel, Elyssa M. Alber, Kathleen F. Vincent, Ken Solt, Cenk Ayata, Andreia Morais, David Y. Chung
[p9] Risk Factor Guided Senolytic Treatment Promotes Angiogenesis, Inhibits Spreading Depolarization and Neuronal Injury in Experimental Ischemic Stroke
Szilvia Kecskes (HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd., Szeged, Hungary; Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged, Hungary), Ákos Menyhárt, Zoltán Veréb, Ferenc Bari, Eszter Farkas
Szilvia Kecskes (HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd., Szeged, Hungary; Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged, Hungary), Ákos Menyhárt, Zoltán Veréb, Ferenc Bari, Eszter Farkas
14:20-15:55Clinical trials
Chair: Jonathan Coles
Chair: Jonathan Coles
14:20-15:00[K2] Designing an escalation clinical trial to address complex pathophysiology in severe TBI/ABI (The INDICT Study)
Keynote: Jed Hartings
Keynote: Jed Hartings
15:00-15:18[P4] S-ketamine versus placebo for cortical spreading depolarisation in patients with severe acute brain injury – KETA-BID trial status
Trine Hjorslev Andreasen (Department of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital − Rigshospitalet, Copenhagen, Denmark), Tobias Sjørslev Bodilsen, Liangchen Guo, Martin Fabricius, Helene Ravnholt Jensen, Ida Møller Nordal, John Hauerberg, Kirsten Møller
Trine Hjorslev Andreasen (Department of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital − Rigshospitalet, Copenhagen, Denmark), Tobias Sjørslev Bodilsen, Liangchen Guo, Martin Fabricius, Helene Ravnholt Jensen, Ida Møller Nordal, John Hauerberg, Kirsten Møller
15:18-15:55Joint discussion: Clinical trials
15:55-16:20Tea break
16:20-16:35Cerebral perfusion and electrophysiology in experimental subarachnoid haemorrhage
Chair: Masumi Tanaka
Chair: Masumi Tanaka
16:20-16:35[O5] The effect of milrinone infusion on Cerebral perfusion and electrophysiological changes following an acute experimental subarachnoid hemorrhage in rat
Valentin Ghibaudo , Gwendan Percevault, Baptiste Balança (Lyon Neuroscience Research Center, Lyon, France)
Valentin Ghibaudo , Gwendan Percevault, Baptiste Balança (Lyon Neuroscience Research Center, Lyon, France)
16:35-17:35Device Implantation and SD Detection
Chair: Masumi Tanaka
Chair: Masumi Tanaka
16:35-16:50[O6] A Novel Device and Procedure for Bedside Subdural Electrode Placement
James Kryzanski (Department of Neurosurgery Tufts Medical Center Boston, MA 02111 USA)
James Kryzanski (Department of Neurosurgery Tufts Medical Center Boston, MA 02111 USA)
16:50-17:05[O7] Quad Lumen Bolt: A novel minimally invasive method for multimodality monitoring in severe traumatic brain injury patients
Asma Khan (Department of Academic Neurosciences and Neurosurgery, Kings College Hospital, London, U.K), Christos Tolias, Anthony Strong
Asma Khan (Department of Academic Neurosciences and Neurosurgery, Kings College Hospital, London, U.K), Christos Tolias, Anthony Strong
17:05-17:20[O8] Safety of electrocorticography monitoring in patients with severe acute brain injury
Tobias Sjørslev Bodilsen (Copenhagen Neuroanaesthesiology and Neurointensive Care Research Group - CONICA), Trine Hjorslev Andreasen, Liangchen Guo, Martin Ejler Fabricius, Kirsten Møller
Tobias Sjørslev Bodilsen (Copenhagen Neuroanaesthesiology and Neurointensive Care Research Group - CONICA), Trine Hjorslev Andreasen, Liangchen Guo, Martin Ejler Fabricius, Kirsten Møller
17:20-17:35[O9] When Do We Miss Spreading Depolarizations? The Role of SD Size and Electrode Configuration in SD Detection
Patrick Dömer (Department of Neurosurgery, Carl von Ossietzky University Oldenburg, Oldenburg, Germany), Simeon OA Helgers, Annika Köhne, Franziska Meinert, Renán Sánchez-Porras, Johannes Woitzik
Patrick Dömer (Department of Neurosurgery, Carl von Ossietzky University Oldenburg, Oldenburg, Germany), Simeon OA Helgers, Annika Köhne, Franziska Meinert, Renán Sánchez-Porras, Johannes Woitzik
17:35-18:00Workshop: Non-invasive detection of SDs
An open discussion led by Prof Bill Shuttleworth
An open discussion led by Prof Bill Shuttleworth
9:00-16:00 Parallel Session: Small Syndicate Room 1
9:00-16:00ICM+ Course
Prof Peter Smielewski & Dr Erta Beqiri (Department of Neurosurgery, University of Cambridge)
Prof Peter Smielewski & Dr Erta Beqiri (Department of Neurosurgery, University of Cambridge)
19:00-22:00Conference Dinner, De Vere Estate: Chapel Dining Hall
DAY 3, DECEMBER 10, WEDNESDAY Balmoral Suite
Chair: Aminul Ahmed (Neurosurgery, King’s College London)
8:45-9:45[K3] Chemistry-directed management of TBI
Keynote: Peter Hutchinson (Department of Neurosurgery, University of Cambridge)
Keynote: Peter Hutchinson (Department of Neurosurgery, University of Cambridge)
9:45-10:25Traumatic Brain Injury and surgery
9:45-10:10[P5] Association of spreading depolarizations (SDs) with measures of cerebral autoregulation and end-organ perfusion in acute, severe TBI
Rachel E. Thomas (Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA), Kseniia Kriukova, Ethan J. Moyer, Justin Moore, Humberto Mestre-Payne, Alex Vaz, Dmitriy Petrov, Dominique Duncan, Danielle K. Sandsmark, Richard Moberg, Brandon Foreman, Ramani Balu, Ramon Diaz-Arrastia
Rachel E. Thomas (Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA), Kseniia Kriukova, Ethan J. Moyer, Justin Moore, Humberto Mestre-Payne, Alex Vaz, Dmitriy Petrov, Dominique Duncan, Danielle K. Sandsmark, Richard Moberg, Brandon Foreman, Ramani Balu, Ramon Diaz-Arrastia
10:10-10:25[O10] Spreading depolarization after extracranial- intracranial bypass surgery
Andrew P Carlson (University of Virginia Department of Neurosurgery), Divine C Nwafor, Lex Fedor, Chaitali Harge, Bill Shuttleworth
Andrew P Carlson (University of Virginia Department of Neurosurgery), Divine C Nwafor, Lex Fedor, Chaitali Harge, Bill Shuttleworth
10:25-10:50Coffee break
Chair: Rob Wykes
10:50-11:50[K4] Interactions of spreading depolarisations and seizures
Keynote: John Jefferys (Universities of Oxford and Prague)
Keynote: John Jefferys (Universities of Oxford and Prague)
11:50-12:30SD, Seizures and channels
11:50-12:15[P6] Regulation of SD susceptibility by interplay between non-inactivating Na+ and K+ currents in genetic epilepsy mice
Isamu Aiba (Department of Neurology, Baylor College of Medicine, Houston, TX, U.S.), Jeffrey Noebels
Isamu Aiba (Department of Neurology, Baylor College of Medicine, Houston, TX, U.S.), Jeffrey Noebels
12:15-12:30[O11] Focal astrocytic Kir4.1 channel knockout drives seizures, spreading depolarisations, and post-ictal impairments in a novel model of TLE
Neela K. Codadu (Research Department of Epilepsy, UCL Queen Square Institute of Neurology, United Kingdom), Yunan Gao, Eduard Masvidal-Codina, Randy Gyimah, Hasna A. Boumenar, Anton Guimera-Brunet, Rob C. Wykes
Neela K. Codadu (Research Department of Epilepsy, UCL Queen Square Institute of Neurology, United Kingdom), Yunan Gao, Eduard Masvidal-Codina, Randy Gyimah, Hasna A. Boumenar, Anton Guimera-Brunet, Rob C. Wykes
12:30-13:15Lunch
13:45-17:45Excursion / Free time
18:30-20:30Dinner in Beaumont Restaurant (shaded purple on the site map). (Closes 21:00)
DAY 4, DECEMBER 11, THURSDAY Balmoral Suite
Chair: Martin Lauritzen (Copenhagen)
8:45-9:45[K5] Neuron-glia metabolic coupling: a cornerstone of brain homeostasis
Keynote: Pierre Magistretti
Keynote: Pierre Magistretti
9:45-10:25Basic neurophysiology
9:45-10:10[P7] Neurovascular functions and transport at the blood-brain barrier
Martin Lauritzen (University of Copenhagen, Denmark)
Martin Lauritzen (University of Copenhagen, Denmark)
10:10-10:25[O12] Intracellular and Extracellular pH Changes Have Distinct Effects on Spreading Depolarization
Ryan Durbin (Department of Physiology and Cell Biology, University of Nevada-Reno, Reno, Nevada, USA), Britta Lindquist, Bill Shuttleworth, Robert Renden
Ryan Durbin (Department of Physiology and Cell Biology, University of Nevada-Reno, Reno, Nevada, USA), Britta Lindquist, Bill Shuttleworth, Robert Renden
10:25-10:50Coffee break
10:50-12:20Basic neurophysiology and CBF
Chair: Jeanette Tas (Linz)
Chair: Jeanette Tas (Linz)
10:50-11:05[O13] ATP depleting spreading depolarizations commonly originate in the somatosensory cortex during oxygen-glucose deprivation in vitro
Karl Schoknecht (Carl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany), Nicolas Höck, Felipe Baeza-Lehnert, Johannes Hirrlinger, Jens P. Dreier, Jens Eilers
Karl Schoknecht (Carl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany), Nicolas Höck, Felipe Baeza-Lehnert, Johannes Hirrlinger, Jens P. Dreier, Jens Eilers
11:05-11:20[O14] Trifluoperazine restores neurovascular function and attenuates the evolution of spreading depolarization after experimental ischemic stroke
Anna Törteli (HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd., Szeged, Hungary), Melinda Szabó, Réka Tóth, Noémi Kovács, Ildikó Horváth, Domokos Máthé, Ákos Menyhárt, Eszter Farkas
Anna Törteli (HCEMM-USZ Cerebral Blood Flow and Metabolism Research Group, HCEMM Nonprofit Ltd., Szeged, Hungary), Melinda Szabó, Réka Tóth, Noémi Kovács, Ildikó Horváth, Domokos Máthé, Ákos Menyhárt, Eszter Farkas
11:20-11:35[O15] Do spreading depolarizations occur in Alzheimer’s disease?
Eszter Farkas (Hungarian Centre of Excellence for Molecular Medicine – University of Szeged Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary), Anna Törteli, Melinda E. Tóth, Rita Frank, Noémi Kovács, Ildikó Horváth, Domokos Máthé, Zsolt Török, Ákos Menyhárt
Eszter Farkas (Hungarian Centre of Excellence for Molecular Medicine – University of Szeged Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary), Anna Törteli, Melinda E. Tóth, Rita Frank, Noémi Kovács, Ildikó Horváth, Domokos Máthé, Zsolt Török, Ákos Menyhárt
11:35-11:50[O16] Effect of long-term optogenetic spreading depolarization stimulation on arterio- and angiogenesis in a mouse model of chronic cerebral hypoperfusion
Annika Köhne (Department of Neurosurgery, Carl von Ossietzky University Oldenburg, Oldenburg, Germany), Patrick Dömer, Simeon OA Helgers, Franziska Meinert, Renán Sánchez-Porras, Maryam Said, Johannes Woitzik
Annika Köhne (Department of Neurosurgery, Carl von Ossietzky University Oldenburg, Oldenburg, Germany), Patrick Dömer, Simeon OA Helgers, Franziska Meinert, Renán Sánchez-Porras, Maryam Said, Johannes Woitzik
11:50-12:05[O17] Direct Cortical Responses during Spreading Depolarisations in the Rat Cortex
Roustem Khazipov (INMED, INSERM UMR1249, Marseille, France), Daria Vinokurova, Azat Nasretdinov, Karina Tukhvatullina, Gulshat Zakirova, Bulat Mingazov, Andrei Zakharov
Roustem Khazipov (INMED, INSERM UMR1249, Marseille, France), Daria Vinokurova, Azat Nasretdinov, Karina Tukhvatullina, Gulshat Zakirova, Bulat Mingazov, Andrei Zakharov
12:05-12:20[O18] Spreading depolarization in ischemic and well-perfused murine brain tissue drives region-specific acute stroke symptoms
Briana Montoya, Andrew K.J. Boyce (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA)
Briana Montoya, Andrew K.J. Boyce (Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA)
12:20-13:15Lunch
13:20-13:55Poster Session 2
Chair: Jed Hartings (Cincinnati)
Chair: Jed Hartings (Cincinnati)
[p10] Persistence-Based Spectrogram Normalization for Robust SD Detection
Chenyu Zhang (Department of Bioengineering and I-X, Imperial College London, SW7 2AZ London, U.K.), Yinzhe Wu, Jeanne Boyer-Chammard, Sharon Jewell, Anthony J. Strong, Guang Yang, Martyn G. Boutelle
Chenyu Zhang (Department of Bioengineering and I-X, Imperial College London, SW7 2AZ London, U.K.), Yinzhe Wu, Jeanne Boyer-Chammard, Sharon Jewell, Anthony J. Strong, Guang Yang, Martyn G. Boutelle
[p11] Multimodal Characterization of Spreading Depolarizations in a Mouse Model of Photothrombotic Distal Middle Cerebral Artery Occlusion (dMCAo)
Alejandro Labastida-Ramirez (Division of Neuroscience, Faculty of Biology, Medicine, and Health; University of Manchester. Manchester, United Kingdom), Lorena Fernandes, Samuel Flaherty, Robert Wykes
Alejandro Labastida-Ramirez (Division of Neuroscience, Faculty of Biology, Medicine, and Health; University of Manchester. Manchester, United Kingdom), Lorena Fernandes, Samuel Flaherty, Robert Wykes
[p12] Detection of spreading depolarisation-associated blood-brain barrier disruption using dynamic contrast-enhanced MRI
Magnus Peter Brammer Kreiberg (Department of Neurology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark), Jakob Møller, Stig Præstekjær Cramer, Ulrich Lindberg, Henrik B. W. Larsson, Anders Hougaard
Magnus Peter Brammer Kreiberg (Department of Neurology, Copenhagen University Hospital – Herlev and Gentofte, Copenhagen, Denmark), Jakob Møller, Stig Præstekjær Cramer, Ulrich Lindberg, Henrik B. W. Larsson, Anders Hougaard
[p13] Glutamate load promotes spreading depolarization under osmotic stress in rat brain slices
Rita Frank (Hungarian Centre of Excellence for Molecular Medicine – University of Szeged Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary), Anne Meiller, Stephane Marinesco, Ferenc Bari, Ákos Menyhárt, Eszter Farkas
Rita Frank (Hungarian Centre of Excellence for Molecular Medicine – University of Szeged Cerebral Blood Flow and Metabolism Research Group, Szeged, Hungary), Anne Meiller, Stephane Marinesco, Ferenc Bari, Ákos Menyhárt, Eszter Farkas
[p14] Measuring spreading depolarisation velocity and propagation using a novel 8-contact strip
Liangchen Guo, Tobias Sjørslev Bodilsen, Trine Hjorslev Andreasen, Thomas Fuglsang, Tea Mužić, Kirsten Møller, Martin Ejler Fabricius (Department of Clinical Neurophysiology, Rigshospitalet University Hospital, Copenhagen, Denmark)
Liangchen Guo, Tobias Sjørslev Bodilsen, Trine Hjorslev Andreasen, Thomas Fuglsang, Tea Mužić, Kirsten Møller, Martin Ejler Fabricius (Department of Clinical Neurophysiology, Rigshospitalet University Hospital, Copenhagen, Denmark)
[p15] Photothrombotic Ring Model in Awake Mice Supports Multiday Penumbra Tracking with Concurrent DC-Coupled Recordings and Blood Flow Imaging
Samuel M. Flaherty (The Division of Neuroscience and the Brain Inflammation Group, University of Manchester, United Kingdom), Anisha Sivakumar, Lorena F. Fernandes, Eduard Masvidal-Codina, Xavi Illa, Elisabet Prats-Alfonso, Kostas Kostarelos, Stuart Allan, Jose A. Garrido, Anton Guimerà-Brunet, Rob C. Wykes
Samuel M. Flaherty (The Division of Neuroscience and the Brain Inflammation Group, University of Manchester, United Kingdom), Anisha Sivakumar, Lorena F. Fernandes, Eduard Masvidal-Codina, Xavi Illa, Elisabet Prats-Alfonso, Kostas Kostarelos, Stuart Allan, Jose A. Garrido, Anton Guimerà-Brunet, Rob C. Wykes
[p16] Traumatic Brain Injury at the King's College Hospital Critical Care Centre (2022-2023)
T. Lalmohamed, J. Fideles, M.Tanaka, L. Colorado (King's College Hospital)
T. Lalmohamed, J. Fideles, M.Tanaka, L. Colorado (King's College Hospital)
[p17] Heterogeneity of Brain Potassium Depletion in Experimental Focal Ischemia
Stephen C. Jones (CerebroScope, Pittsburgh, PA, USA), Alexander Kharlamov, Victor E. Yushmanov
Stephen C. Jones (CerebroScope, Pittsburgh, PA, USA), Alexander Kharlamov, Victor E. Yushmanov
14:00-15:00Circulation and outcome
Chair: Jens Dreier (Berlin)
Chair: Jens Dreier (Berlin)
14:00-14:15[O19] Investigating Spreading Depolarizations Frequency and Network Activity in Different Injuries
Lex Fedor (University of Virginia, Department of Neurosurgery), Andrew Carlson
Lex Fedor (University of Virginia, Department of Neurosurgery), Andrew Carlson
14:15-14:30[O20] Elevated CSF Iron and Zinc Levels are Associated with Early Poor Outcomes after Aneurysmal SAH
Emily Dunbar (Department of Neurosurgery, University of Virginia, Virginia, USA), Chaitali Harge, Tanvika Vegiraju, David Loftus, Matthew Campen, Eliane Hayek, William Shuttleworth, Andrew Carlson
Emily Dunbar (Department of Neurosurgery, University of Virginia, Virginia, USA), Chaitali Harge, Tanvika Vegiraju, David Loftus, Matthew Campen, Eliane Hayek, William Shuttleworth, Andrew Carlson
14:30-14:45[O21] Outcome prediction after subarachnoid hemorrhage based on initial clinical scores and initial CT is significant but rather poor
Vasilis Kola, Prabin Basnet, Viktor Horst, Sebastian Major, Coline L. Lemale, Nils Hecht, Jed A. Hartings, Johannes Woitzik, Peter Martus, Jens P. Dreier (Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, Germany)
Vasilis Kola, Prabin Basnet, Viktor Horst, Sebastian Major, Coline L. Lemale, Nils Hecht, Jed A. Hartings, Johannes Woitzik, Peter Martus, Jens P. Dreier (Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, Germany)
14:30-14:45[O22] Scalp EEG Spreading Depolarization Biomarker Burden is Associated with Functional Outcome of Cardiac Arrest Patients in the Multicenter I-CARE Cohort
Eric S. Rosenthal (Mass General Brigham Department of Neurology), John McNamee, Alireza Chamanzar, David Y. Chung, Morteza Zabihi
Eric S. Rosenthal (Mass General Brigham Department of Neurology), John McNamee, Alireza Chamanzar, David Y. Chung, Morteza Zabihi
15:00-15:45“Hot topics discussion”
Chair: Bill Shuttleworth
Chair: Bill Shuttleworth
15:45-16:00Presentations (TBC): iCSD2026
Conclusion: Sharon Jewell
Conclusion: Sharon Jewell